Effects of Amino Acid Substitutions at Position 115 on the Fidelity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

We compared the fidelity of wild-type human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) and two RT mutants, Y115F and Y115V. Although neither mutation had a large effect on the overall fidelity of the enzyme, both mutations altered the spectrum of mutations and the precise natur...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Boyer, Paul L., Hughes, Stephen H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Recombination and Evolution
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112158/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10864662/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.14.6494-6500.2000
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