Rearrangement of interstrand cross-links into intrastrand cross-links in cis-diamminedichloroplatinum(II)-modified DNA.

In the reaction of the anticancer drug cis-diamminedichloroplatinum(II) (cis-DDP) with DNA, bifunctional intrastrand and interstrand cross-links are formed. In this work, we show that at 37 degrees C interstrand cross-links (ICL) are labile and rearrange into intrastrand cross-links. The ICL instabi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pérez, C, Leng, M, Malinge, J M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1997
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC146515/
https://ncbi.nlm.nih.gov/pubmed/9016644
Etiketak: Etiketa erantsi
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