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Critical role of stearoyl-CoA desaturase–1 (SCD1) in the onset of diet-induced hepatic insulin resistance

Stearoyl-CoA desaturase–1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids from saturated fatty acids. Mice with a targeted disruption of Scd1 gene locus are lean and display increased insulin sensitivity. To examine whether Scd1 activity is required for the development of diet-induced...

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Detalhes bibliográficos
Main Authors: Gutiérrez-Juárez, Roger, Pocai, Alessandro, Mulas, Claudia, Ono, Hiraku, Bhanot, Sanjay, Monia, Brett P., Rossetti, Luciano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464900/
https://ncbi.nlm.nih.gov/pubmed/16741579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26991
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