The subcellular localization and length of hammerhead ribozymes determine efficacy in human cells.

The length requirements of the antisense portion of hammerhead ribozymes for efficacy in living cells was investigated. The HIV-1tat-directed asymmetric hammerhead ribozyme alphaYRz195 was used with a 195 nt 3'-antisense arm and a 3 nt 5'-antisense portion as well as a set of successively 3'-shorten...

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Εκδόθηκε σε:	Nucleic Acids Res
Κύριοι συγγραφείς:	Hormes, R, Homann, M, Oelze, I, Marschall, P, Tabler, M, Eckstein, F, Sczakiel, G
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Oxford University Press 1997
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146489/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9016627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.4.769
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