The subcellular localization and length of hammerhead ribozymes determine efficacy in human cells.

The length requirements of the antisense portion of hammerhead ribozymes for efficacy in living cells was investigated. The HIV-1tat-directed asymmetric hammerhead ribozyme alphaYRz195 was used with a 195 nt 3'-antisense arm and a 3 nt 5'-antisense portion as well as a set of successively 3'-shorten...

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Vydáno v:	Nucleic Acids Res
Hlavní autoři:	Hormes, R, Homann, M, Oelze, I, Marschall, P, Tabler, M, Eckstein, F, Sczakiel, G
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 1997
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146489/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9016627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.4.769
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