The subcellular localization and length of hammerhead ribozymes determine efficacy in human cells.

The length requirements of the antisense portion of hammerhead ribozymes for efficacy in living cells was investigated. The HIV-1tat-directed asymmetric hammerhead ribozyme alphaYRz195 was used with a 195 nt 3'-antisense arm and a 3 nt 5'-antisense portion as well as a set of successively 3'-shorten...

Полное описание

Библиографические подробности

Опубликовано в::	Nucleic Acids Res
Главные авторы:	Hormes, R, Homann, M, Oelze, I, Marschall, P, Tabler, M, Eckstein, F, Sczakiel, G
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Oxford University Press 1997
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146489/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9016627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.4.769
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