The subcellular localization and length of hammerhead ribozymes determine efficacy in human cells.

The length requirements of the antisense portion of hammerhead ribozymes for efficacy in living cells was investigated. The HIV-1tat-directed asymmetric hammerhead ribozyme alphaYRz195 was used with a 195 nt 3'-antisense arm and a 3 nt 5'-antisense portion as well as a set of successively 3'-shorten...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Hormes, R, Homann, M, Oelze, I, Marschall, P, Tabler, M, Eckstein, F, Sczakiel, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146489/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9016627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.4.769
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