Mutational spectrometry without phenotypic selection: human mitochondrial DNA.

By first separating mutant from nonmutant DNA sequences on the basis of their melting temperatures and then increasing the number of copies by high-fidelity DNA amplification, we have developed a method that allows observation of point mutations in biological samples at fractions at or above 10-6. U...

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Main Authors: Khrapko, K, Coller, H, André, P, Li, X C, Foret, F, Belenky, A, Karger, B L, Thilly, W G
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC146488/
https://ncbi.nlm.nih.gov/pubmed/9016616
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