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Evaluation of pyrimidine PNA binding to ssDNA targets from nonequilibrium melting experiments.

Slow kinetics of homopyrimidine PNA binding to single stranded DNA and RNA targets is manifested in significant hysteresis in thermal UV absorption experiments. We have compared temperatures of dissociation (Tdis) and reassociation (Tass) for triplexes formed by DNA and single or bis PNAs with K50 d...

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Udgivet i:Nucleic Acids Res
Principais autores: Lesnik, E A, Risen, L M, Driver, D A, Griffith, M C, Sprankle, K, Freier, S M
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146474/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9016597/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.3.568
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