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Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication

Summary: It has been long assumed that normally leading strand synthesis must proceed coordinated with the lagging strand to prevent strand uncoupling and the pathological accumulation of single-stranded DNA (ssDNA) in the cell, a dogma recently challenged by in vitro studies in prokaryotes. Here, w...

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Autores principales: Amaia Ercilla, Jan Benada, Sampath Amitash, Gijs Zonderland, Giorgio Baldi, Kumar Somyajit, Fena Ochs, Vincenzo Costanzo, Jiri Lukas, Luis Toledo
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020-02-01
Colección:Cell Reports
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S2211124720300929
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