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Role of extracellular Ca(2+) in gating of Ca(V)1.2 channels
We examined changes in ionic and gating currents in Ca(V)1.2 channels when extracellular Ca(2+) was reduced from 10 mm to 0.1 μm. Saturating gating currents decreased by two-thirds (K(D)≈ 40 μm) and ionic currents increased 5-fold (K(D)≈ 0.5 μm) due to increasing Na(+) conductance. A biphasic time d...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1464545/ https://ncbi.nlm.nih.gov/pubmed/15845581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.086561 |
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