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Block of Ca(V)1.2 Channels by Gd(3+) Reveals Preopening Transitions in the Selectivity Filter
Using the lanthanide gadolinium (Gd(3+)) as a Ca(2+) replacing probe, we investigated the voltage dependence of pore blockage of Ca(V)1.2 channels. Gd(+3) reduces peak currents (tonic block) and accelerates decay of ionic current during depolarization (use-dependent block). Because diffusion of Gd(3...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2151628/ https://ncbi.nlm.nih.gov/pubmed/17535959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200709733 |
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