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Simulations of calcium channel block by trivalent cations: Gd(3+) competes with permeant ions for the selectivity filter
Current through L-type calcium channels (Ca(V)1.2 or dihydropyridine receptor) can be blocked by micromolar concentrations of trivalent cations like the lanthanide gadolinium (Gd(3+)). It has been proposed that trivalent block is due to ions competing for a binding site in both the open and closed c...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2946232/ https://ncbi.nlm.nih.gov/pubmed/20696128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2010.08.001 |
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