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Simulations of calcium channel block by trivalent cations: Gd(3+) competes with permeant ions for the selectivity filter

Current through L-type calcium channels (Ca(V)1.2 or dihydropyridine receptor) can be blocked by micromolar concentrations of trivalent cations like the lanthanide gadolinium (Gd(3+)). It has been proposed that trivalent block is due to ions competing for a binding site in both the open and closed c...

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Bibliographische Detailangaben
Hauptverfasser: Malasics, Attila, Boda, Dezső, Valiskó, Mónika, Henderson, Douglas, Gillespie, Dirk
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946232/
https://ncbi.nlm.nih.gov/pubmed/20696128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2010.08.001
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