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Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins.

The antitumor agent cis-diamminedichloroplatinum(II) (cisplatin) introduces cytotoxic DNA damage predominantly in the form of intrastrand crosslinks between adjacent purines. Binding assays using a series of duplex oligonucleotides containing a single 1,2 diguanyl intrastrand crosslink indicate that...

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Udgivet i:Nucleic Acids Res
Principais autores: Yamada, M, O'Regan, E, Brown, R, Karran, P
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146450/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9016586/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.3.491
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