HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease.

The most frequent DNA adduct made by the anticancer drug cisplatin, the 1,2-intrastrand d(GpG) cross-link, as well as the minor 1,3-intrastrand d(GpTpG) adduct, were both repaired by an in vitro human excision repair system. Fragments of 27-29 nt containing the platinum damage were excised. The high...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Huang, J C, Zamble, D B, Reardon, J T, Lippard, S J, Sancar, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45026/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937961/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.22.10394
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!