HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease.

The most frequent DNA adduct made by the anticancer drug cisplatin, the 1,2-intrastrand d(GpG) cross-link, as well as the minor 1,3-intrastrand d(GpTpG) adduct, were both repaired by an in vitro human excision repair system. Fragments of 27-29 nt containing the platinum damage were excised. The high...

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הוצא לאור ב:	Proc Natl Acad Sci U S A
Principais autores:	Huang, J C, Zamble, D B, Reardon, J T, Lippard, S J, Sancar, A
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	National Academy of Sciences 1994
נושאים:	Research Article
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45026/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937961/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.22.10394
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