The pharmacokinetics of imipenem (thienamycin-formamidine) and the renal dehydropeptidase inhibitor cilastatin sodium in normal subjects and patients with renal failure.

The antibiotic imipenum (thienamycin-formamidine) is partially hydrolyzed during excretion by a renal brush border dehydropeptidase. The co-administration of imipenum with the renal dehydropeptidase inhibitor cilastatin results in an increase of the urinary recovery of the antibiotic, both in animal...

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Bibliografiske detaljer
Main Authors: Verpooten, G A, Verbist, L, Buntinx, A P, Entwistle, L A, Jones, K H, De Broe, M E
Format: Artigo
Sprog:Inglês
Udgivet: 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463530/
https://ncbi.nlm.nih.gov/pubmed/6593092
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