SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1–dependent inflammatory arthritis

RA is an autoimmune disease characterized by sustained imbalance between pro- and antiinflammatory immune mechanisms. The SOCS proteins are negative regulators of cytokine signaling, but to date there has been little information on their function in disease. The generation of Socs3(–/Δvav) mice, whi...

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Hauptverfasser: Wong, Peter K.K., Egan, Paul J., Croker, Ben A., O’Donnell, Kristy, Sims, Natalie A., Drake, Sarah, Kiu, Hiu, McManus, Edward J., Alexander, Warren S., Roberts, Andrew W., Wicks, Ian P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2006
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462939/
https://ncbi.nlm.nih.gov/pubmed/16710471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25660
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