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Changing effective population size and the McDonald-Kreitman test.

Artifactual evidence of adaptive amino acid substitution can be generated within a McDonald-Kreitman test if some amino acid mutations are slightly deleterious and there has been an increase in effective population size. Here I investigate the conditions under which this occurs. I show that fairly s...

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Autor principal: Eyre-Walker, Adam
Format: Artigo
Idioma:Inglês
Publicat: 2002
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462352/
https://ncbi.nlm.nih.gov/pubmed/12524367
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