Stepwise unfolding of titin under force-clamp atomic force microscopy

Here we demonstrate the implementation of a single-molecule force clamp adapted for use with an atomic force microscope. We show that under force-clamp conditions, an engineered titin protein elongates in steps because of the unfolding of its modules and that the waiting times to unfold are exponent...

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Main Authors: Oberhauser, Andres F., Hansma, Paul K., Carrion-Vazquez, Mariano, Fernandez, Julio M.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC14610/
https://ncbi.nlm.nih.gov/pubmed/11149943
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