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Stepwise Unfolding of Ankyrin Repeats in a Single Protein Revealed by Atomic Force Microscopy
Using single-molecule atomic force microscopy, we find that a protein consisting of six identical ankyrin repeat units flanked by N- and C-terminal modules (N6C) unfolds in a stepwise, unit-by-unit fashion under a mechanical force. Stretching a N6C molecule results in a sawtooth pattern fingerprint,...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Biophysical Society
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1367297/ https://ncbi.nlm.nih.gov/pubmed/16387766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.078436 |
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