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Use of a small palindrome genetic marker to investigate mechanisms of double-strand-break repair in mammalian cells.

We examined mechanisms of mammalian homologous recombination using a gene targeting assay in which the vector-borne region of homology to the chromosome bore small palindrome insertions that frequently escape mismatch repair when encompassed within heteroduplex DNA (hDNA). Our assay permitted the pr...

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Detalhes bibliográficos
Main Authors: Li, J, Baker, M D
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1460998/
https://ncbi.nlm.nih.gov/pubmed/10757769
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