Expression of 5-lipoxygenase and leukotriene A(4) hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability

Leukotrienes (LT) are a group of proinflammatory lipid mediators that are implicated in the pathogenesis and progression of atherosclerosis. Here we report that mRNA levels for the three key proteins in LTB(4) biosynthesis, namely 5-lipoxygenase (5-LO), 5-LO-activating protein (FLAP), and LTA(4) hyd...

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Main Authors: Qiu, Hong, Gabrielsen, Anders, Agardh, Hanna E., Wan, Min, Wetterholm, Anders, Wong, Chi-Huey, Hedin, Ulf, Swedenborg, Jesper, Hansson, Göran K., Samuelsson, Bengt, Paulsson-Berne, Gabrielle, Haeggström, Jesper Z.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459628/
https://ncbi.nlm.nih.gov/pubmed/16698924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602414103
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