Cysteinyl Leukotriene Signaling Aggravates Myocardial Hypoxia in Experimental Atherosclerotic Heart Disease

BACKGROUND: Cysteinyl-leukotrienes (cys-LT) are powerful spasmogenic and immune modulating lipid mediators involved in inflammatory diseases, in particular asthma. Here, we investigated whether cys-LT signaling, in the context of atherosclerotic heart disease, compromises the myocardial microcircula...

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Hlavní autoři: Nobili, Elena, Salvado, M. Dolores, Folkersen, Lasse, Castiglioni, Laura, Kastrup, Jens, Wetterholm, Anders, Tremoli, Elena, Hansson, Göran K., Sironi, Luigi, Haeggström, Jesper Z., Gabrielsen, Anders
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404957/
https://ncbi.nlm.nih.gov/pubmed/22848603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041786
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