Structural Instability of the Prion Protein upon M205S/R Mutations Revealed by Molecular Dynamics Simulations

The point mutations M205S and M205R have been demonstrated to severely disturb the folding and maturation process of the cellular prion protein (PrP(C)). These disturbances have been interpreted as consequences of mutation-induced structural changes in PrP, which are suggested to involve helix 1 and...

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Bibliographische Detailangaben
Hauptverfasser: Hirschberger, Thomas, Stork, Martina, Schropp, Bernhard, Winklhofer, Konstanze F., Tatzelt, Jörg, Tavan, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: Biophysical Society 2006
Schlagworte:
Biophysical Theory and Modeling
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459491/
https://ncbi.nlm.nih.gov/pubmed/16513786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.075341
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