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Human Ape2 protein has a 3′–5′ exonuclease activity that acts preferentially on mismatched base pairs

DNA damage, such as abasic sites and DNA strand breaks with 3′-phosphate and 3′-phosphoglycolate termini present cytotoxic and mutagenic threats to the cell. Class II AP endonucleases play a major role in the repair of abasic sites as well as of 3′-modified termini. Human cells contain two class II...

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Bibliografiske detaljer
Main Authors: Burkovics, Peter, Szukacsov, Valeria, Unk, Ildiko, Haracska, Lajos
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459411/
https://ncbi.nlm.nih.gov/pubmed/16687656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl259
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