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Human Ape2 protein has a 3′–5′ exonuclease activity that acts preferentially on mismatched base pairs
DNA damage, such as abasic sites and DNA strand breaks with 3′-phosphate and 3′-phosphoglycolate termini present cytotoxic and mutagenic threats to the cell. Class II AP endonucleases play a major role in the repair of abasic sites as well as of 3′-modified termini. Human cells contain two class II...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1459411/ https://ncbi.nlm.nih.gov/pubmed/16687656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl259 |
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