Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor

The host restriction factor TRIM5α mediates species-specific, early blocks to retrovirus infection; susceptibility to these blocks is determined by viral capsid sequences. Here we demonstrate that TRIM5α variants from Old World monkeys specifically associate with the HIV type 1 (HIV-1) capsid and th...

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Bibliographic Details
Main Authors: Stremlau, Matthew, Perron, Michel, Lee, Mark, Li, Yuan, Song, Byeongwoon, Javanbakht, Hassan, Diaz-Griffero, Felipe, Anderson, Donovan J., Sundquist, Wesley I., Sodroski, Joseph
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459386/
https://ncbi.nlm.nih.gov/pubmed/16540544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509996103
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