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Physically realistic homology models built with rosetta can be more accurate than their templates

We have developed a method that combines the rosetta de novo protein folding and refinement protocol with distance constraints derived from homologous structures to build homology models that are frequently more accurate than their templates. We test this method by building complete-chain models for...

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Библиографические подробности
Главные авторы: Misura, Kira M. S., Chivian, Dylan, Rohl, Carol A., Kim, David E., Baker, David
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459360/
https://ncbi.nlm.nih.gov/pubmed/16567638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509355103
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