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Physically realistic homology models built with rosetta can be more accurate than their templates

We have developed a method that combines the rosetta de novo protein folding and refinement protocol with distance constraints derived from homologous structures to build homology models that are frequently more accurate than their templates. We test this method by building complete-chain models for...

詳細記述

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書誌詳細
主要な著者: Misura, Kira M. S., Chivian, Dylan, Rohl, Carol A., Kim, David E., Baker, David
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459360/
https://ncbi.nlm.nih.gov/pubmed/16567638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509355103
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