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Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes
Deformylase inhibitors belong to a novel antibiotic class that targets peptide deformylase, a bacterial enzyme that removes the formyl group from N-terminal methionine in nascent polypeptides. Using the bacterium Salmonella enterica, we isolated mutants with resistance toward the peptide deformylase...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1459004/ https://ncbi.nlm.nih.gov/pubmed/16636273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602171103 |
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