Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

Forkhead winged-helix transcription factor Foxp3 serves as the dedicated mediator of the genetic program governing CD25(+)CD4(+) regulatory T cell (T(r)) development and function in mice. In humans, its role in mediating T(r) development has been controversial. Furthermore, the fate of T(r) precurso...

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Main Authors: Gavin, Marc A., Torgerson, Troy R., Houston, Evan, deRoos, Paul, Ho, William Y., Stray-Pedersen, Asbjørg, Ocheltree, Elizabeth L., Greenberg, Philip D., Ochs, Hans D., Rudensky, Alexander Y.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458937/
https://ncbi.nlm.nih.gov/pubmed/16617117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509484103
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