Potent antisense oligonucleotides to the human multidrug resistance-1 mRNA are rationally selected by mapping RNA-accessible sites with oligonucleotide libraries.

Antisense oligonucleotides can vary significantly and unpredictably in their ability to inhibit protein synthesis. Libraries of chimeric oligonucleotides and RNase H were used to cleave and thereby locate sites on human multidrug resistance-1 RNA transcripts that are relatively accessible to oligonu...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Ho, S P, Britton, D H, Stone, B A, Behrens, D L, Leffet, L M, Hobbs, F W, Miller, J A, Trainor, G L
Формат: Artigo
Язык:Inglês
Опубликовано: 1996
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC145867/
https://ncbi.nlm.nih.gov/pubmed/8657572
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы