Structure of human Wilson protein domains 5 and 6 and their interplay with domain 4 and the copper chaperone HAH1 in copper uptake

Human Wilson protein is a copper-transporting ATPase located in the secretory pathway possessing six N-terminal metal-binding domains. Here we focus on the function of the metal-binding domains closest to the vesicular portion of the copper pump, i.e., domain 4 (WLN4), and a construct of domains 5 a...

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Bibliographic Details
Main Authors: Achila, David, Banci, Lucia, Bertini, Ivano, Bunce, Jennifer, Ciofi-Baffoni, Simone, Huffman, David L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2006
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458641/
https://ncbi.nlm.nih.gov/pubmed/16571664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504472103
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