Regulation of Cre recombinase activity by the synthetic steroid RU 486.

To create a strategy for inducible gene targeting we developed a Cre-lox recombination system which responds to the synthetic steroid RU 486. Several fusions between Cre recombinase and the hormone binding domain (HBD) of a mutated human progesterone receptor, which binds RU 486 but not progesterone...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Kellendonk, C, Tronche, F, Monaghan, A P, Angrand, P O, Stewart, F, Schütz, G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145830/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8628671/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.8.1404
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