Regulation of Cre recombinase activity by the synthetic steroid RU 486.

To create a strategy for inducible gene targeting we developed a Cre-lox recombination system which responds to the synthetic steroid RU 486. Several fusions between Cre recombinase and the hormone binding domain (HBD) of a mutated human progesterone receptor, which binds RU 486 but not progesterone...

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Autori principali: Kellendonk, C, Tronche, F, Monaghan, A P, Angrand, P O, Stewart, F, Schütz, G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC145830/
https://ncbi.nlm.nih.gov/pubmed/8628671
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