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NMR investigations of duplex stability of phosphorothioate and phosphorodithioate DNA analogues modified in both strands.

Duplex formation from the self-complementary 12mer d(CGCGAATTCGCG) (Dickerson dodecamer) in which all phosphodiester linkages were replaced by phosphorothioate or phosphorodithioate linkages was studied using variable-temperature 1H and 31P NMR spectroscopy. Melting temperatures of the dodecamer, me...

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Udgivet i:Nucleic Acids Res
Principais autores: Jaroszewski, J W, Clausen, V, Cohen, J S, Dahl, O
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145729/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8600448/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.5.829
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