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PDGF regulates the actin cytoskeleton through hnRNP-K-mediated activation of the ubiquitin E(3)-ligase MIR
PDGF is a potent chemotactic mitogen and a strong inductor of fibroblast motility. In Swiss 3T3 fibroblasts, exposure to PDGF but not EGF or IGF-1 causes a rapid loss of actin stress fibers (SFs) and focal adhesions (FAs), which is followed by the development of retractile dendritic protrusions and...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1456933/ https://ncbi.nlm.nih.gov/pubmed/16619033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601059 |
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