PDGF regulates the actin cytoskeleton through hnRNP-K-mediated activation of the ubiquitin E(3)-ligase MIR

PDGF is a potent chemotactic mitogen and a strong inductor of fibroblast motility. In Swiss 3T3 fibroblasts, exposure to PDGF but not EGF or IGF-1 causes a rapid loss of actin stress fibers (SFs) and focal adhesions (FAs), which is followed by the development of retractile dendritic protrusions and...

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Bibliografiske detaljer
Main Authors: Nagano, Kohji, Bornhauser, Beat C, Warnasuriya, Gayathri, Entwistle, Alan, Cramer, Rainer, Lindholm, Dan, Naaby-Hansen, Soren
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456933/
https://ncbi.nlm.nih.gov/pubmed/16619033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601059
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