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Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice

Survivin is a cancer gene implicated in inhibition of apoptosis and regulation of mitosis, but its function in normal cells has remained elusive. Here, we show that transgenic mice expressing survivin in pancreatic islet β-cells show no changes in cell proliferation, as determined by islet size or i...

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Библиографические подробности
Главные авторы: Dohi, Takehiko, Salz, Whitney, Costa, Marco, Ariyan, Charlotte, Basadonna, Giacomo P, Altieri, Dario C
Формат: Artigo
Язык:Inglês
Опубликовано: 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456913/
https://ncbi.nlm.nih.gov/pubmed/16470228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400640
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