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Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice

Survivin is a cancer gene implicated in inhibition of apoptosis and regulation of mitosis, but its function in normal cells has remained elusive. Here, we show that transgenic mice expressing survivin in pancreatic islet β-cells show no changes in cell proliferation, as determined by islet size or i...

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書誌詳細
主要な著者: Dohi, Takehiko, Salz, Whitney, Costa, Marco, Ariyan, Charlotte, Basadonna, Giacomo P, Altieri, Dario C
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456913/
https://ncbi.nlm.nih.gov/pubmed/16470228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400640
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