Rapid and efficient hybridization-triggered crosslinking within a DNA duplex by an oligodeoxyribonucleotide bearing a conjugated cyclopropapyrroloindole.

The antitumor antibiotic CC-1065 binds in the minor groove of double-stranded DNA, and the cyclopropapyrroloindole (CPI) subunit of the drug alkylates adjacent adenines at their N-3 position. We have attached racemic CPI to oligodeoxyribonucleotides (ODNs) via a terminal phosphorothioate at either t...

Full description

Saved in:
Bibliographic Details
Main Authors: Lukhtanov, E A, Podyminogin, M A, Kutyavin, I V, Meyer, R B, Gamper, H B
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC145684/
https://ncbi.nlm.nih.gov/pubmed/8604310
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items