Rapid and efficient hybridization-triggered crosslinking within a DNA duplex by an oligodeoxyribonucleotide bearing a conjugated cyclopropapyrroloindole.

The antitumor antibiotic CC-1065 binds in the minor groove of double-stranded DNA, and the cyclopropapyrroloindole (CPI) subunit of the drug alkylates adjacent adenines at their N-3 position. We have attached racemic CPI to oligodeoxyribonucleotides (ODNs) via a terminal phosphorothioate at either t...

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Vydáno v:	Nucleic Acids Res
Hlavní autoři:	Lukhtanov, E A, Podyminogin, M A, Kutyavin, I V, Meyer, R B, Gamper, H B
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 1996
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145684/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8604310/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.4.683
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Rapid and efficient hybridization-triggered crosslinking within a DNA duplex by an oligodeoxyribonucleotide bearing a conjugated cyclopropapyrroloindole.

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