TNF-alpha-mediated expression of membrane-type matrix metalloproteinase in rheumatoid synovial fibroblasts.

Degradation of the extracellular matrix plays an important role in rheumatoid articular destruction. Rheumatoid synovial fibroblasts secrete a large amount of matrix-degrading metalloproteinases (MMPs), which initiate tissue damage by proteolytic degradation of collagens and proteoglycans. Cytokines...

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Autores principales: Migita, K, Eguchi, K, Kawabe, Y, Ichinose, Y, Tsukada, T, Aoyagi, T, Nakamura, H, Nagataki, S
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456590/
https://ncbi.nlm.nih.gov/pubmed/9014820
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