Effects of rapamycin on apoptosis of rheumatoid synovial cells

In the present study, we investigated the effects of an immunosuppressant, rapamycin, on bcl-2 expression and the susceptibility of human rheumatoid synovial fibroblasts to Fas-mediated apoptosis. Rapamycin treatment down-regulated bcl-2 expression on rheumatoid synovial cells in a dose-dependent ma...

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Bibliographic Details
Main Authors: MIGITA, K, EGUCHI, K, ICHINOSE, Y, KAWABE, Y, TSUKADA, T, AOYAGI, T, NAGATAKI, S
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 1997
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904668/
https://ncbi.nlm.nih.gov/pubmed/9158086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1997.d01-1002.x
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