Unwinding of the third strand of a DNA triple helix, a novel activity of the SV40 large T-antigen helicase.

We present experiments indicating that the SV40 large T-antigen (T-ag) helicase is capable of unwinding the third strand of DNA triple helices. Intermolecular d(TC)(20)d(GA)(20)d(TC)(20) triplexes were generated by annealing, at pH 5.5, a linearized double-stranded plasmid containing a d(TC)(27).d(G...

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Bibliographic Details
Main Authors: Kopel, V, Pozner, A, Baran, N, Manor, H
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC145642/
https://ncbi.nlm.nih.gov/pubmed/8628658
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