Presenilin-Based Genetic Screens in Drosophila melanogaster Identify Novel Notch Pathway Modifiers

Presenilin is the enzymatic component of γ-secretase, a multisubunit intramembrane protease that processes several transmembrane receptors, such as the amyloid precursor protein (APP). Mutations in human Presenilins lead to altered APP cleavage and early-onset Alzheimer's disease. Presenilins a...

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Autores principales: Mahoney, Matt B., Parks, Annette L., Ruddy, David A., Tiong, Stanley Y. K., Esengil, Hanife, Phan, Alexander C., Philandrinos, Panos, Winter, Christopher G., Chatterjee, Runa, Huppert, Kari, Fisher, William W., L'Archeveque, Lynn, Mapa, Felipa A., Woo, Wendy, Ellis, Michael C., Curtis, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: Copyright © 2006 by the Genetics Society of America 2006
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Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456381/
https://ncbi.nlm.nih.gov/pubmed/16415372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.035170
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