Efficient Gene Targeting in Drosophila With Zinc-Finger Nucleases

This report describes high-frequency germline gene targeting at two genomic loci in Drosophila melanogaster, y and ry. In the best case, nearly all induced parents produced mutant progeny; 25% of their offspring were new mutants and most of these were targeted gene replacements resulting from homolo...

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Bibliografski detalji
Glavni autori: Beumer, Kelly, Bhattacharyya, Gargi, Bibikova, Marina, Trautman, Jonathan K., Carroll, Dana
Format: Artigo
Jezik:Inglês
Izdano: Copyright © 2006 by the Genetics Society of America 2006
Teme:
Investigations
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456366/
https://ncbi.nlm.nih.gov/pubmed/16452139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.052829
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