Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

We have determined the 3.0 Å resolution structure of wild-type HIV-1 reverse transcriptase in complex with an RNA:DNA oligonucleotide whose sequence includes a purine-rich segment from the HIV-1 genome called the polypurine tract (PPT). The PPT is resistant to ribonuclease H (RNase H) cleavage and i...

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Autores principales: Sarafianos, Stefan G., Das, Kalyan, Tantillo, Chris, Clark, Arthur D., Ding, Jianping, Whitcomb, Jeannette M., Boyer, Paul L., Hughes, Stephen H., Arnold, Edward
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2001
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC145536/
https://ncbi.nlm.nih.gov/pubmed/11250910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.6.1449
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