A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor

Stimulation of T cells via the CD3–T-cell receptor (TCR) complex results in rapid increases in β1 integrin-mediated adhesion via poorly defined intracellular signaling events. We demonstrate that TCR-mediated activation of β1 integrins requires activation of the Tec family tyrosine kinase Itk and ph...

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Main Authors: Woods, Melody L., Kivens, Wendy J., Adelsman, Margaret A., Qiu, Yun, August, Avery, Shimizu, Yoji
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2001
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC145515/
https://ncbi.nlm.nih.gov/pubmed/11250890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.6.1232
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